Robustness-strength Performance of Hierarchical Alpha-helical Protein Filaments

نویسندگان

  • ZHAO QIN
  • STEVEN CRANFORD
  • THEODOR ACKBAROW
  • MARKUS J BUEHLER
چکیده

ZHAO QIN∗,†, STEVEN CRANFORD∗,†, THEODOR ACKBAROW∗,‡ and MARKUS J BUEHLER∗,†,§,¶ ∗Laboratory for Atomistic and Molecular Mechanics Department of Civil and Environmental Engineering Massachusetts Institute of Technology 77 Massachusetts Ave., Room 1-235A&B Cambridge, MA, USA †Center for Materials Science and Engineering Massachusetts Institute of Technology 77 Massachusetts Ave., Cambridge, MA, USA ‡Max Planck Institute of Colloids and Interfaces Theory Division, Science Park Golm 14424 Potsdam, Germany §Center for Computational Engineering Massachusetts Institute of Technology 77 Massachusetts Ave., Cambridge, MA, USA ¶[email protected]

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Alpha-helical protein domains unify strength and robustness through hierarchical nanostructures.

Hierarchical nanostructures, ranging through atomistic, molecular and macroscopic scales, represent universal features of biological protein materials. Here we show for the case of alpha-helical (AH) protein domains that this use of molecular hierarchies within the structural arrangement leads to an extended physical dimension in the material design space that resolves the conflict between disp...

متن کامل

How protein materials balance strength, robustness, and adaptability.

Proteins form the basis of a wide range of biological materials such as hair, skin, bone, spider silk, or cells, which play an important role in providing key functions to biological systems. The focus of this article is to discuss how protein materials are capable of balancing multiple, seemingly incompatible properties such as strength, robustness, and adaptability. To illustrate this, we rev...

متن کامل

Molecular dynamics simulation of the α-helix to β-sheet transition in coiled protein filaments: evidence for a critical filament length scale.

The alpha-helix to beta-sheet transition (α-β transition) is a universal deformation mechanism in alpha-helix rich protein materials such as wool, hair, hoof, and cellular proteins. Through a combination of molecular and theoretical modeling, we examine the behavior of alpha-helical coiled-coil proteins with varying lengths under stretch. We find that the occurrence of the α-β transition is con...

متن کامل

NANO- AND MICROMECHANICAL PROPERTIES OF HIERARCHICAL BIOLOGICAL MATERIALS Superelasticity, energy dissipation and strain hardening of vimentin coiled-coil intermediate filaments: atomistic and continuum studies

Vimentin coiled-coil alpha-helical dimers are elementary protein building blocks of intermediate filaments, an important component of the cell’s cytoskeleton that has been shown to control the large-deformation behavior of eukaryotic cells. Here we use a combination of atomistic simulation and continuum theory to model tensile and bending deformation of single alpha-helices as well as coiled-co...

متن کامل

Nanomechanical strength mechanisms of hierarchical biological materials and tissues.

Biological protein materials (BPMs), intriguing hierarchical structures formed by assembly of chemical building blocks, are crucial for critical functions of life. The structural details of BPMs are fascinating: They represent a combination of universally found motifs such as alpha-helices or beta-sheets with highly adapted protein structures such as cytoskeletal networks or spider silk nanocom...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2009